Francis (Francesco) Caracciolo was born in Villa Santa Maria in the Abruzzo region, in the Kingdom of Naples. He belonged to the Pisquizio branch of the Caracciolo family and received in baptism the name of Ascanio. From a young age, he had a reputation for gentleness and uprightness. When he was 22, he was attacked by one of the several skin maladies collectively described as "leprosy" in those days. So serious was this attack that he was considered hopeless. With death so near, he made a vow that if he regained his health, he would spend the rest of his life in the service of God and his fellow men. He recovered so quickly after this vow, that his cure was considered miraculous. Eager to fulfil his promise to God, he went to Naples to study for the priesthood.